Visitors are advised that the Kruger National Park and adjoining areas fall within the malaria zone, and precautionary measures should be taken when entering this region. Surveys have suggested that the chance of an average visitor getting malaria is roughly 1 in 24,000.

Safety for visitors: Most malaria cases occur in the wet season between October and May, with the months February to May being the peak risk period. During these months visitors are advised to use anti-malarial medication. Most malaria advisors recommend a combination of daily Paludrine and weekly chroloquine (commercial names Daramal, Nivaquine, Plasmoquine etc.), or a weekly dose of Larium. Minimise the contact with mosquitoes by applying repellent substances such as Tabard or a number of other products, burning mosquito coils or using vaporising mats, and wearing socks and shoes during the evening.